All About Intrauterine Insemination: Procedure, Costs, and Success Rates

Image of the authorWritten by Philomena Marx9th January 2025
Intrauterine Insemination (IUI)

Intrauterine insemination (IUI) is a proven method to support infertile couples. This article provides a brief overview of the procedure, costs, and success rates of this treatment method.

What is Intrauterine Insemination (IUI)?

Intrauterine Insemination (IUI) is a medical procedure in which sperm is directly placed into the uterus to facilitate fertilisation. "Intrauterine" means "within the uterus", while "insemination" refers to "semen transfer". This procedure can be carried out with the partner's sperm (homologous insemination) or donor sperm (heterologous insemination).

Why is IUI Performed? The Most Common Reasons for Intrauterine Insemination

IUI is often considered in the following situations:

  • Mild Sperm Quality Issues: In men with slightly reduced sperm count or motility.
  • Irregular Ovulation: In women with irregular ovulation, which can make fertilisation more difficult.
  • Unexplained Infertility: In couples where the cause of infertility remains unknown despite regular intercourse.
  • Single Women or Lesbian Couples: For women who wish to start a family on their own or in same-sex relationships.

Requirements and Criteria for Intrauterine Insemination (IUI)

To achieve a successful IUI, certain conditions must be met:

  • Healthy Reproductive Tract: The woman must have a healthy reproductive system, particularly open and healthy fallopian tubes.
  • Regular Ovulation: Either natural or hormonally induced ovulation must be present.
  • No Hereditary Diseases: There should be no hereditary conditions in the family that could be passed on to offspring.
  • Fertile Sperm: The male partner must produce sufficiently fertile sperm.

Step-by-Step: The IUI Procedure with Hormonal Stimulation

To increase the chances of pregnancy, hormonal stimulation of the ovaries is often performed prior to IUI. The IUI procedure with hormonal stimulation involves the following steps:

  1. Preliminary Tests and Consultation: Both partners undergo thorough tests to determine the cause of infertility. This includes blood tests, hormone analyses, and ultrasounds. Following this, a detailed consultation with the medical team takes place.
  2. Ovarian Stimulation: The woman receives hormonal medications to stimulate her ovaries to produce multiple eggs. Progress is monitored through ultrasounds and blood tests.
  3. Egg Retrieval: Once the eggs are sufficiently mature, they are retrieved under sedation or general anaesthesia. The eggs are immediately sent to the laboratory.
  4. Sperm Collection: Parallel to egg retrieval, a sperm sample is collected from the male partner or a donor. If necessary, sperm can also be obtained through a testicular biopsy.
  5. Sperm Preparation: The sperm sample is processed in the laboratory, where the healthiest and most motile sperm are selected.
  6. Sperm Injection: The processed sperm is inserted directly into the woman's uterus using a catheter. This step requires precision to place the sperm as close as possible to the egg area.
  7. Fertilisation Monitoring: The fertilised eggs are cultured in an incubator for several days, and their growth is carefully monitored.
  8. Embryo Transfer: After culturing, the best embryos are selected and transferred into the woman's uterus.
  9. Pregnancy Test: About two weeks after the embryo transfer, a pregnancy test is performed to check the success of the treatment.
  10. Pregnancy and Birth: If the pregnancy is successful, the woman is closely monitored throughout the pregnancy.

Each step of the IUI procedure is aimed at creating the optimal conditions for successful fertilisation and pregnancy.

The Benefits of Intrauterine Insemination (IUI) at a Glance

Compared to natural conception, IUI offers several advantages:

  • Direct Placement of Sperm: The processed, motile sperm is placed directly near the ovulation site, increasing the chances of fertilisation.
  • Hormonal Stimulation: Hormonal stimulation of the ovaries can increase the number of available eggs, significantly boosting the success rate.
  • Cost-Effective: IUI is generally more affordable than more invasive methods like in vitro fertilisation (IVF).
  • Less Invasive: The procedure is less invasive and does not require complicated surgical interventions.

Success Rates and Chances of Success with Intrauterine Insemination (IUI)

The probability of pregnancy per IUI attempt is typically around 10-15%, depending on various factors:

  • Age of the Woman: Younger women generally have higher success rates.
  • Sperm Quality: Good sperm quality improves fertilisation chances.
  • Timing in the Cycle: Precise ovulation timing is crucial for success.

Typically, 3 to 6 attempts are made. If unsuccessful, IVF is often recommended. Many couples, however, successfully achieve parenthood through IUI.

Costs of Intrauterine Insemination (IUI) and Insurance Coverage

The costs of IUI vary depending on the fertility clinic, ranging from £300 to £1,000, including medications. Under certain conditions, such as marriage, age criteria, and using the partner's sperm, the National Health Service (NHS) covers 50% of the costs.

Potential Risks and Side Effects of Intrauterine Insemination (IUI)

Although IUI is generally considered safe, there are some potential risks and side effects to consider:

  • Ovarian Hyperstimulation Syndrome (OHSS): Hormonal stimulation can cause overstimulation of the ovaries, leading to swelling and discomfort.
  • Infections: Though rare, there is a slight risk of infection from the insertion of catheters into the uterus.
  • Multiple Pregnancies: Hormonal stimulation can lead to multiple eggs being produced, increasing the risk of twins or multiples.
  • Discomfort or Pain: Some women may experience mild pain or discomfort during or after the procedure.

Alternative Approaches to Intrauterine Insemination (IUI)

In addition to IUI, there are alternative methods for treating fertility issues:

  • Natural Insemination: A less interventionist method where sperm is introduced during natural ovulation.
  • In Vitro Fertilisation (IVF): A more comprehensive method where eggs and sperm are fertilised in the laboratory, and the embryos are then transferred into the uterus.
  • Intracytoplasmic Sperm Injection (ICSI): An advanced technique where individual sperm are injected directly into the eggs to aid fertilisation.

Alternative RattleStork

In addition to traditional methods of artificial insemination, our platform RattleStork offers a private and flexible way to fulfil the desire for children. Here, couples and individuals can directly communicate with sperm donors to find personalised solutions.

RattleStork.org – the sperm donation app
Figure: RattleStork.org – the sperm donation app

Conclusion: Intrauterine Insemination (IUI) as an Effective Method for Family Planning

Intrauterine insemination (IUI) is an affordable and less invasive option for achieving the desire to have children. By precisely placing the sperm into the uterus, the chances of a successful pregnancy are significantly increased. Personalised advice from specialists is essential to achieve the best outcomes.